PhD Positions in Voltage Imaging for Neuroscience

Department/faculty: Applied Sciences
Level: Master degree
Working hours: 38 hours per week
Contract: 4 years
Salary: €2222 to €2840

Applied Sciences

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The Faculty of Applied Sciences has a strong programme in Imaging Physics in which new instrumentation and new methods are developed for microscopy and medical imaging. The Imaging Physics programme has led to innovations in electron microscopy, lithography, light microscopy, ultrasound imaging, terahertz imaging, focused ion beam milling, plus many quantitative image processing methods. Most of the instruments in the lab are prototypes with unique functionalities. Instrumentation is developed in collaboration with scientific and industrial users for evaluation and first scientific observations.

PhD positions are available in the new Neuroimaging lab ( at Delft University of Technology. We are building a multidisciplinary team to work on voltage imaging, at the interface of optical physics, molecular biology, and neuroscience. This includes design of innovative optical imaging schemes, creation of new and improved voltage sensors, biophysical interpretation of voltage imaging data, and application in neuroscientific studies.
We value a collaborative environment, both within the lab and between labs. Joint appointments with Erasmus MC Rotterdam are a possibility.

Job description

Voltage imaging is the optical detection of cellular electrical signalling. It promises new neuroscientific insights through the imaging of circuit dynamics deep in the living brain at previously inaccessible scales of time and space, detailed biophysical understanding of cellular signaling through detection of membrane voltage dynamics in subcellular compartments, and new avenues of disease modelling and therapeutic research through massively parallel recording of neural dynamics.
You’ll work on a multidisciplinary project at the cutting edge of this developing field.
Potential projects include:
• Nanoscopic investigations of signalling dynamics in synapses
• Investigation of developing zebrafish brains through absolute voltage imaging
• Development of multiphoton voltage imaging techniques for mouse brains.


You have a background in neuroscience, optogenetics, molecular biology, chemistry, physics or nanotechnology, and an interest in multidisciplinary science. Examples of desirable experience include: experimental microscopy, nanophotonics or electrophysiology; design/construction of imaging setups; data analysis/modelling; tissue slice/in vivo experiments (zebrafish/mouse); behavioral training; protein engineering; cloning; tissue culturing or DAQ programming.
You communicate well in English, are happy to learn skills out of your comfort zone and actively engage collaborators outside the lab.

Conditions of employment

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.
As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit for more information.

Information and application

For more information about this position, please contact Dr. D. Brinks, phone: +31 (0)15-2788161, e-mail: To apply, please e-mail a detailed CV with a letter of application, a research statement summarising previous work experience and research interests, and contact information of references to Ms. J.T. van Vliet, This vacancy will remain open until suitable candidates have been found.
When applying for this position, please refer to vacancy number TNWIP17-044.

Enquiries from agencies are not appreciated.


Applied Sciences
Master degree
Working hours
4 years
€2222 to €2840

Closing date
Oct. 31, 2017
Vacancy nr.


For more information about this job, please contact D. Brinks, Staff member.

T +31 (0)15-2788161

For more information about the application procedure, please contact D. Brinks/Imaging Physics.