PhD on biomarkers of radiation-induced toxicity from advanced MR imaging

Faculteit/afdeling: Faculty Applied Sciences
Niveau: Universitair
Functie-omvang: 38.0 uur per week
Contractduur: 4 years
Salaris: 2325 - 2972 euro per maand (volledige dagtaak)
U bekijkt een vacaturetekst oorspronkelijk opgesteld in het Engels.
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Faculty Applied Sciences

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The position is in the Department of Imaging Physics ( This department performs cutting-edge research spanning the range from understanding the basic principles underlying imaging technology to automated image analysis.    

Functie omschrijving

The research performed in this project concerns a strong collaboration between TU Delft,  Holland PTC, Leiden UMC, and Erasmus MC.

A key treatment modality of brain tumours is radiotherapy. However, conventional radiotherapy can have a detrimental effect on the surrounding healthy tissue. Proton therapy is a promising new form of therapy that improves the preservation of the healthy tissue.

Advanced MRI techniques can quantify changes in brain tissue already very early after radiotherapy. The recruited PhD will develop new markers of radiation toxicity from MR perfusion and diffusion imaging. In particular, the research will focus on creating new MRI acquisition schemes and novel techniques to process the data (e.g. machine learning approaches). Enhanced information will be obtained from knowledge of the physical principles underlying MR image acquistion and the brain's vasculature.

The research especially targets brain tumor patients undergoing photon and proton radiotherapy.

The PhD candidate will be based at TU Delft. Simultaneously, we foresee that an important part of the research will take place in our partnering medical institutes.

The project is funded by Holland PTC. HollandPTC’s mission is to provide patients with the best proton therapy presently available, in a safe and welcoming environment, where they are treated with care and diligence. You will be part of the HollandPTC R&D program. Its mission is to prove the added value of proton therapy, which we do in cooperation with the national and international radiotherapy and oncology community. 

Functie eisen

We are looking for a talented and enthusiastic PhD candidate with an MSc degree in (applied) physics, mathematics, electrical engineering or a related subject. He/she must have an excellent knowledge of written and spoken English, and a top 20% ranking during his/her BSc and MSc. Experience with MRI and image processing is helpful. Good programming skills in MATLAB and C are a necessity. 


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit for more information.

Informeren en solliciteren

For more information about this position, please contact Dr. Frans Vos, phone: +31 (0)15-2787133, e-mail: If you are interested in this position, please send the following information in English (pdf format only):

1) a letter of motivation,

2) a detailed CV (containing amongst others a list of publications, a summary of your MSc thesis),

3) the names and contact details of three references,

4) A certified copy of your BSc and MSc degree*

5) A certified copy of the transcript of records belonging to your BSc and MSc degree*

Please e-mail your application to Mrs. Annelies van Beek,, referring to vacancy number TNWIP19-025. The position will close on 30 September 2019.

* If the documents are not written in Dutch, English, French or German: a certified translation is mandatory.

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.


Faculty Applied Sciences
38.0 uur per week
4 years
2325 - 2972 euro per maand (volledige dagtaak)

1 oktober 2019


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